If you are like me, you may be working from a laptop with an attached external monitor. I am using a ViewSonic 24 inch which has brilliant crisp colours and size compared to my laptop screen so preferably I would want to to simply set it as my primary monitor. This however does not seem to be possible (in Vista at least) as the option "This is my main monitor" in Display Settings is greyed out for the second screen.
However, one little trick I didn't know was even possible is that if you unlock your taskbar (found by right clicking on an area of it) you can actually drag your task bar to the second screen which you can benefit from immediately (I realised you could drag it around the screen just not send it to another screen :)).
My next annoyance was the awesome ObjectDock still being stuck on my laptop screen - this however can also be moved across using the following setting in it's options:
Solid.